Top 25 College Hoops Picks Against the Spread – Saturday, February 22
Published 8:28 pm Friday, February 21, 2025
A total of 15 games on the Saturday college basketball schedule feature a ranked team, including the matchup between the Tennessee Volunteers and the Texas A&M Aggies. Below, we provide against-the-spread picks for each contest.
Place your bets on any men’s college basketball matchup at BetMGM. Sign up today using our link.
AP Top 25 Picks ATS Today
No. 7 Texas A&M Aggies vs. No. 6 Tennessee Volunteers
Spread Prediction
- Computer Prediction: Tennessee 69, Texas A&M 68
- Projected Favorite: Tennessee by 1.1 points
- Pick ATS: Tennessee (+2.5)
Bet on the Texas A&M-Tennessee spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 12 p.m. ET
- Location: College Station, Texas
- Venue: Reed Arena
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 25 Louisville Cardinals vs. Florida State Seminoles
Spread Prediction
- Computer Prediction: Louisville 80, Florida State 68
- Projected Favorite: Louisville by 11.9 points
- Pick ATS: Florida State (+13.5)
Bet on the Louisville-Florida State spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 12 p.m. ET
- Location: Louisville, Kentucky
- Venue: KFC Yum! Center
- TV Channel: The CW
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 11 Wisconsin Badgers vs. Oregon Ducks
Spread Prediction
- Computer Prediction: Wisconsin 79, Oregon 71
- Projected Favorite: Wisconsin by 8.2 points
- Pick ATS: Oregon (+8.5)
Bet on the Wisconsin-Oregon spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 12 p.m. ET
- Location: Madison, Wisconsin
- Venue: Kohl Center
- TV Channel: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 9 Texas Tech Red Raiders vs. West Virginia Mountaineers
Spread Prediction
- Computer Prediction: Texas Tech 75, West Virginia 66
- Projected Favorite: Texas Tech by 8.1 points
- Pick ATS: West Virginia (+11.5)
Bet on the Texas Tech-West Virginia spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 1 p.m. ET
- Location: Lubbock, Texas
- Venue: United Supermarkets Arena
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
Oklahoma Sooners vs. No. 21 Mississippi State Bulldogs
Spread Prediction
- Computer Prediction: Mississippi State 76, Oklahoma 74
- Projected Favorite: Mississippi State by 2.1 points
- Pick ATS: Oklahoma (+3.5)
Bet on the Oklahoma-Mississippi State spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 1 p.m. ET
- Location: Norman, Oklahoma
- Venue: Lloyd Noble Center
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 5 Houston Cougars vs. No. 8 Iowa State Cyclones
Spread Prediction
- Computer Prediction: Houston 74, Iowa State 67
- Projected Favorite: Houston by 6.7 points
- Pick ATS: Iowa State (+12.5)
Bet on the Houston-Iowa State spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 2 p.m. ET
- Location: Houston, Texas
- Venue: Fertitta Center
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Vanderbilt Commodores vs. No. 24 Ole Miss Rebels
Spread Prediction
- Computer Prediction: Ole Miss 76, Vanderbilt 74
- Projected Favorite: Ole Miss by 2.2 points
- Pick ATS: Ole Miss (+1.5)
Bet on the Vanderbilt-Ole Miss spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 3:30 p.m. ET
- Location: Nashville, Tennessee
- Venue: Memorial Gymnasium
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 1 Auburn Tigers vs. Georgia Bulldogs
Spread Prediction
- Computer Prediction: Auburn 82, Georgia 66
- Projected Favorite: Auburn by 15.9 points
- Pick ATS: Georgia (+17.5)
Bet on the Auburn-Georgia spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 4 p.m. ET
- Location: Auburn, Alabama
- Venue: Neville Arena
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 23 Kansas Jayhawks vs. Oklahoma State Cowboys
Spread Prediction
- Computer Prediction: Kansas 80, Oklahoma State 66
- Projected Favorite: Kansas by 13.8 points
- Pick ATS: Oklahoma State (+14.5)
Bet on the Kansas-Oklahoma State spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 4 p.m. ET
- Location: Lawrence, Kansas
- Venue: Allen Fieldhouse
- TV Channel: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
SMU Mustangs vs. No. 18 Clemson Tigers
Spread Prediction
- Computer Prediction: SMU 75, Clemson 74
- Projected Favorite: SMU by 1 points
- Pick ATS: SMU (+1.5)
Bet on the SMU-Clemson spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 4 p.m. ET
- Location: Dallas, Texas
- Venue: Moody Coliseum
- TV Channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
LSU Tigers vs. No. 2 Florida Gators
Spread Prediction
- Computer Prediction: Florida 80, LSU 70
- Projected Favorite: Florida by 9.5 points
- Pick ATS: LSU (+10.5)
Bet on the LSU-Florida spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 6 p.m. ET
- Location: Baton Rouge, Louisiana
- Venue: Pete Maravich Assembly Center
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 4 Alabama Crimson Tide vs. No. 17 Kentucky Wildcats
Spread Prediction
- Computer Prediction: Alabama 86, Kentucky 80
- Projected Favorite: Alabama by 5.9 points
- Pick ATS: Kentucky (+9.5)
Bet on the Alabama-Kentucky spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 6 p.m. ET
- Location: Tuscaloosa, Alabama
- Venue: Coleman Coliseum
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 3 Duke Blue Devils vs. Illinois Fighting Illini
Spread Prediction
- Computer Prediction: Duke 78, Illinois 71
- Projected Favorite: Duke by 7.4 points
- Pick ATS: Illinois (+9.5)
Bet on the Duke-Illinois spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 8 p.m. ET
- Location: New York City, New York
- Venue: Madison Square Garden
- TV Channel: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Arkansas Razorbacks vs. No. 15 Missouri Tigers
Spread Prediction
- Computer Prediction: Missouri 75, Arkansas 74
- Projected Favorite: Missouri by 1.4 points
- Pick ATS: Arkansas (+1.5)
Bet on the Arkansas-Missouri spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 8 p.m. ET
- Location: Fayetteville, Arkansas
- Venue: Bud Walton Arena
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
No. 19 Arizona Wildcats vs. BYU Cougars
Spread Prediction
- Computer Prediction: Arizona 77, BYU 72
- Projected Favorite: Arizona by 4.9 points
- Pick ATS: BYU (+7.5)
Bet on the Arizona-BYU spread—or any other NCAA men’s basketball matchup—with BetMGM!
Key Facts
- Time: 10 p.m. ET
- Location: Tucson, Arizona
- Venue: McKale Center
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.