Top 25 College Hoops Picks Against the Spread – Saturday, February 22

Published 8:28 pm Friday, February 21, 2025

A total of 15 games on the Saturday college basketball schedule feature a ranked team, including the matchup between the Tennessee Volunteers and the Texas A&M Aggies. Below, we provide against-the-spread picks for each contest.

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AP Top 25 Picks ATS Today

No. 7 Texas A&M Aggies vs. No. 6 Tennessee Volunteers

Spread Prediction

  • Computer Prediction: Tennessee 69, Texas A&M 68
  • Projected Favorite: Tennessee by 1.1 points
  • Pick ATS: Tennessee (+2.5)

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Bet on the Texas A&M-Tennessee spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 12 p.m. ET
  • Location: College Station, Texas
  • Venue: Reed Arena
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 25 Louisville Cardinals vs. Florida State Seminoles

Spread Prediction

  • Computer Prediction: Louisville 80, Florida State 68
  • Projected Favorite: Louisville by 11.9 points
  • Pick ATS: Florida State (+13.5)

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Key Facts

  • Time: 12 p.m. ET
  • Location: Louisville, Kentucky
  • Venue: KFC Yum! Center
  • TV Channel: The CW
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 11 Wisconsin Badgers vs. Oregon Ducks

Spread Prediction

  • Computer Prediction: Wisconsin 79, Oregon 71
  • Projected Favorite: Wisconsin by 8.2 points
  • Pick ATS: Oregon (+8.5)

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Key Facts

  • Time: 12 p.m. ET
  • Location: Madison, Wisconsin
  • Venue: Kohl Center
  • TV Channel: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 9 Texas Tech Red Raiders vs. West Virginia Mountaineers

Spread Prediction

  • Computer Prediction: Texas Tech 75, West Virginia 66
  • Projected Favorite: Texas Tech by 8.1 points
  • Pick ATS: West Virginia (+11.5)

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Key Facts

  • Time: 1 p.m. ET
  • Location: Lubbock, Texas
  • Venue: United Supermarkets Arena
  • TV Channel: ESPN+
  • Live Stream: Watch this game on ESPN+

Oklahoma Sooners vs. No. 21 Mississippi State Bulldogs

Spread Prediction

  • Computer Prediction: Mississippi State 76, Oklahoma 74
  • Projected Favorite: Mississippi State by 2.1 points
  • Pick ATS: Oklahoma (+3.5)

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Key Facts

  • Time: 1 p.m. ET
  • Location: Norman, Oklahoma
  • Venue: Lloyd Noble Center
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 5 Houston Cougars vs. No. 8 Iowa State Cyclones

Spread Prediction

  • Computer Prediction: Houston 74, Iowa State 67
  • Projected Favorite: Houston by 6.7 points
  • Pick ATS: Iowa State (+12.5)

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Key Facts

  • Time: 2 p.m. ET
  • Location: Houston, Texas
  • Venue: Fertitta Center
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Vanderbilt Commodores vs. No. 24 Ole Miss Rebels

Spread Prediction

  • Computer Prediction: Ole Miss 76, Vanderbilt 74
  • Projected Favorite: Ole Miss by 2.2 points
  • Pick ATS: Ole Miss (+1.5)

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Key Facts

  • Time: 3:30 p.m. ET
  • Location: Nashville, Tennessee
  • Venue: Memorial Gymnasium
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 1 Auburn Tigers vs. Georgia Bulldogs

Spread Prediction

  • Computer Prediction: Auburn 82, Georgia 66
  • Projected Favorite: Auburn by 15.9 points
  • Pick ATS: Georgia (+17.5)

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Key Facts

  • Time: 4 p.m. ET
  • Location: Auburn, Alabama
  • Venue: Neville Arena
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 23 Kansas Jayhawks vs. Oklahoma State Cowboys

Spread Prediction

  • Computer Prediction: Kansas 80, Oklahoma State 66
  • Projected Favorite: Kansas by 13.8 points
  • Pick ATS: Oklahoma State (+14.5)

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Key Facts

  • Time: 4 p.m. ET
  • Location: Lawrence, Kansas
  • Venue: Allen Fieldhouse
  • TV Channel: CBS
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

SMU Mustangs vs. No. 18 Clemson Tigers

Spread Prediction

  • Computer Prediction: SMU 75, Clemson 74
  • Projected Favorite: SMU by 1 points
  • Pick ATS: SMU (+1.5)

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Key Facts

  • Time: 4 p.m. ET
  • Location: Dallas, Texas
  • Venue: Moody Coliseum
  • TV Channel: ACC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

LSU Tigers vs. No. 2 Florida Gators

Spread Prediction

  • Computer Prediction: Florida 80, LSU 70
  • Projected Favorite: Florida by 9.5 points
  • Pick ATS: LSU (+10.5)

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Key Facts

  • Time: 6 p.m. ET
  • Location: Baton Rouge, Louisiana
  • Venue: Pete Maravich Assembly Center
  • TV Channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 4 Alabama Crimson Tide vs. No. 17 Kentucky Wildcats

Spread Prediction

  • Computer Prediction: Alabama 86, Kentucky 80
  • Projected Favorite: Alabama by 5.9 points
  • Pick ATS: Kentucky (+9.5)

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Key Facts

  • Time: 6 p.m. ET
  • Location: Tuscaloosa, Alabama
  • Venue: Coleman Coliseum
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 3 Duke Blue Devils vs. Illinois Fighting Illini

Spread Prediction

  • Computer Prediction: Duke 78, Illinois 71
  • Projected Favorite: Duke by 7.4 points
  • Pick ATS: Illinois (+9.5)

Bet on the Duke-Illinois spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8 p.m. ET
  • Location: New York City, New York
  • Venue: Madison Square Garden
  • TV Channel: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Arkansas Razorbacks vs. No. 15 Missouri Tigers

Spread Prediction

  • Computer Prediction: Missouri 75, Arkansas 74
  • Projected Favorite: Missouri by 1.4 points
  • Pick ATS: Arkansas (+1.5)

Bet on the Arkansas-Missouri spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 8 p.m. ET
  • Location: Fayetteville, Arkansas
  • Venue: Bud Walton Arena
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

No. 19 Arizona Wildcats vs. BYU Cougars

Spread Prediction

  • Computer Prediction: Arizona 77, BYU 72
  • Projected Favorite: Arizona by 4.9 points
  • Pick ATS: BYU (+7.5)

Bet on the Arizona-BYU spread—or any other NCAA men’s basketball matchup—with BetMGM!

Key Facts

  • Time: 10 p.m. ET
  • Location: Tucson, Arizona
  • Venue: McKale Center
  • TV Channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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